A single-center prospective observational study. This study examines urine flow and haemodynamic parameters during abdominal surgery and analyses the association to postoperative renal function and markers and to postoperative clinical outcome. Primary hypothesis: • Within a goal-directed haemodynamic protocol during gynecologic cancer surgery there are phases of temporary anuria. Secondary hypothesis: * Perioperative anuric phases are directly associated to the postoperative increase of NGAL (neutrophil gelatinase-associated lipocalin) and creatinine * Perioperative renal dysfunction is directly associated to postoperative complications and functional recovery of patients * A response of urine flow to a standardized postoperative diuretic bolus can identify patients who benefit from a pharmaceutical fluid mobilization * Within a goal-directed haemodynamic protocol during gynaecologic cancer surgery, the methods for the measurement of stroke volume of the heart differ
Study Type
OBSERVATIONAL
Department of Anesthesiology and Intensive Care Medicine, Campus Virchow Klinikum, Charité - Universitaetsmedizin
Berlin, State of Berlin, Germany
Exact measurement of urine production
Exact measurement of urine production (number of anuric episodes anf duration of anuric episodes in minutes)
Time frame: During the operation and in the 72-hour postoperative sample period
Exact measurement of urine production
Exact measurement of urine production (amount in milliliter)
Time frame: During the operation and in the 72-hour postoperative sample period
Biomarker for renal injury, Neutrophil gelatinase-associated lipocalin (NGAL) and creatinine
Parameters from blood sample
Time frame: During the operation and in the 72-hour postoperative sample period
Hemodynamic parameters
Time frame: During the operation
Blood loss
Time frame: During the operation
Depth of Anesthesia
Measuring depth of Anesthesia by Bispectral Index Monitoring
Time frame: During the operation
Organ dysfunctions
Time frame: During the operation and in the 72-hour postoperative sample period
Postoperative pain
Time frame: In the 72-hour postoperative sample period
Body weight development
Time frame: In the 72-hour postoperative sample period
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Duration until fulfilment of hospital discharge criteria
Time frame: Participants will be followed for the duration of an expected average of 4 weeks
ICU and hospital length of stay
Time frame: Participants will be followed for the duration of intensive care unit stay and hospital stay, an expected average of 4 weeks
Quality of life and functional status
Time frame: Participants will be followed for the duration of hospital stay, an exspected average of 4 weeks
Inflammatory parameters
Time frame: In the 72-hour postoperative sample period
Amount of vasopressors
Time frame: During the operation and in the 72-hour postoperative sample period