Kinetics of Fluvoxamine and Digoxin in Subjects With Different MDR1 Genotypes

Inclusion Criteria: * \- Healthy volunteer ≥ 18 years of age * Normal kidney function as measured by GFR according to Cockroft-Gault (70-120 ml/min) * Normal P-potassiumvalue (3,6-4,6 mmol/L) * HF\>50 and no AV-block on resting ECG. No other significant abnormalities as judged by the investigator. * Subject giving written informed consent * Subject capable of understanding instructions Exclusion Criteria: * \- Pregnancy * Ongoing infection * Intake of medication, including natural remedies (for example St John´s wort), within one month prior to starting study except for paracetamol. * Active drug or alcohol abuse