The purpose of the study is to investigate the metabolic effects during acute inflammation with and without the nutritional supplement of amino acids. E. Coli Endotoxin (LPS, lipopolysaccharide) is used to initiate an inflammatory response. The study is an interventional randomized placebo study including 8 healthy male subjects. Each subject participates 3 times (different days) and are given one of following interventions: * Placebo (NaCl) * Endotoxin, US standard reference E.Coli + Placebo (NaCl) * Endotoxin, US standard reference E.Coli + Amino acids (intravenously) It is our hypothesis that the nutritional intervention during acute inflammation plays an important role in lipid and protein metabolism.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
8
Medical Department MEA, NBG, Aarhus University Hospital
Aarhus C, Jylland, Denmark
Protein catabolism during acute illness
Protein catabolism is measured with amino acid tracer techniques comparing radioactive marked amino acids from blood samples.
Time frame: After 6 hours intervention
The local effects on muscle and fat tissue
A muscle + fat biopsy are taken twice during the intervention to focus on the local effects in these tissues.
Time frame: At 2 hours and 4,5 hours
Other systemic metabolic effects during acute illness
Lipid and glucose metabolism are measured with tracer techniques with radioactive marked glucose + lipid.
Time frame: 6 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.