Beetroot Enriched Bread, Blood Pressure and Vascular Function

University of Reading24 enrolled

Overview

Dietary nitrate is known to lower blood pressure. Beetroot is a rich source of nitrate and could therefore be an important dietary component in the management of hypertension and cardiovascular disease, however consumption is relatively low. We evaluated the effects of beetroot enriched bread ingestion on acute microvascular reactivity, arterial stiffness and blood pressure response in healthy men.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Hypertension

Interventions

BreadDIETARY_SUPPLEMENT

Eligibility

Sex: MALEMin age: 18 YearsMax age: 64 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male * A signed consent form * Age 18-64 years * Body mass index - 18.5-30 kg/m2 * Non-smoking, healthy individuals * Normal blood pressure at screening (\< 150/90) Exclusion Criteria: * Subjects with anaemia * Sufferers of chronic illnesses * Individuals with food allergies * People with diabetes * People with coeliac disease * Women * Vegetarians

Locations (1)

University of Reading

Reading, Berkshire, United Kingdom

Outcomes

Primary Outcomes

Vascular reactivity

Forearm blood flow by Laser Doppler Imaging with iontophoresis

Time frame: Change from baseline at 2, 4 and 6 hours after bread consumption

Secondary Outcomes

Arterial stiffness

Pulse wave analysis (PWA) and velocity (PWV)

Time frame: Change from baseline at 2, 4 and 6 hours after bread consumption

Blood pressure

By ambulatory blood pressure monitor

Time frame: Change from baseline at 30 minute intervals for 7 hours

Plasma nitrate

Time frame: Every 30 minutes for 7 hours

Plasma nitrite

Time frame: Every 30 minutes for 7 hours

Data from ClinicalTrials.gov

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