Genetic Determinant of Blood Pressure Sensitivity to Salt Intake

Assistance Publique - Hôpitaux de Paris219 enrolled

Overview

Nedd4.2 is a regulator of ENac, a transporter of sodium involved in the regulation of salt retention by the kidney. The study address the consequence of a frequent genetic variation leading expected to impact the function of Nedd4 and in turn, the ability of kidneys to excrete salt intake. Our hypothesis is that the genetic variants of Nedd4.2 could constitute a genetic predisposition to (or protection against) salt-sensitive hypertension.

Subjects were submitted one week to a low sodium-high potassium diet, and then switch to a high sodium,-low potassium diet for two weeks. the last week, subject were taken a 20 MG daily dose of amiloride, a potassium sparing diuretic.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

219

Conditions

Hypertension

Interventions

Diet AmilorideOTHER

only arm of the trial

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy volunteers * between 18 and 35 years odl * BMI between 18 and 28 Kg per m2 * non smokers * no active disease * no alcool or drug abuse

Outcomes

Primary Outcomes

Difference in Blood Pressure among genotypes

24h AMBP will be measured weekly for the duration of study, an expected average of 3 weeks

Time frame: 24h AMBP will be measured weekly for the duration of study, an expected average of 3 weeks

Secondary Outcomes

Ambulatory Blood Pressure (AMBP)

24h AMBP was measured fourth : at the beginning of the study,at the end of the low sodium-high potassium diet, after one week under the high sodium-low potassium diet and at the end of amiloride treatment under high sodium-low potassium diet

Time frame: three weeks

Data from ClinicalTrials.gov

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