Acupuncture for Persistent Insomnia Associated With Major Depressive Disorder

Inclusion Criteria: * Aged 18 years or above * A previous Diagnostic and Statistical Manual of Mental Disorders-IV Major Depressive Disorder * Have a current Diagnostic and Statistical Manual of Mental Disorders-IV diagnosis of insomnia disorder * Insomnia more than 3 nights per week for at least 3 months * Insomnia Severity Scale (ISI) total score higher than 15 at screening and baseline visit * Use of antidepressants at the same dosage for at least 12 weeks prior to screening visit * Hypnotic dosage has not been increased in the last 4 weeks Exclusion Criteria: * Have a Hamilton Depression Rating Scale scores above 18 * Have sleep apnea or periodic limbs movement disorder detected by overnight polysomnography * Have suicidal risk as assessed by the Hamilton Depression Rating Scale suicidal risk item * Have previous history of schizophrenia, other psychotic disorders, and bipolar disorder * Have current alcohol or drug abuse and dependence * Pregnant, breast-feeding, or woman of childbearing potential not using adequate contraception * Have infection or abscess close to the site of selected acupoints and in the investigator's opinion inclusion is unsafe * Taking Chinese herbal medicine or over-the-counter drugs which are intending for insomnia within the last 2 weeks prior to baseline or during the study * Any acupuncture treatment during the previous 12 months prior to baseline and * Unstable medical conditions.