The aim of this study is to examine the efficacy of 5 mg Midodrine (Gutron) vs. placebo on reducing the incidence of orthostatic hypotension during mobilization 6 h after a total hip arthroplasty.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
120
Gentofte Hospital, Department of orthopaedic surgery
Hellerup, Denmark
Hvidovre Hospital, Department of orthopaedic surgery
Hvidovre, Denmark
Vejle Sygehus, Department of orthopedic surgery
Vejle, Denmark
Orthostatic hypotension
Orthostatic hypotension (OH) during early mobilization 6 hours after end of surgery. OH is classified according to international consensus.
Time frame: 6 hours after surgery
Orthostatic hypotension 24 hours after surgery
Time frame: 24 hours after end of surgery.
Orthostatic Intolerance
Orthostatic intolerance is defined as subjective presyncopal symptoms (dizziness, nausea etc.) during mobilization after surgery
Time frame: 6 and 24 hours after end of surgery
Treatment side effects
The following side effects to Midodrine are evaluated: * Pruritus * Headache * Supine hypertension * Urinary retention
Time frame: 6 and 24 hours after end of surgery
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