Mechanisms Behind Antidiabetic Effects by Gastric By-pass

Karolinska Institutet15 enrolled

Overview

The aim of the study is to develop new strategies in treatment of continuous increasing number of patients with type 2 diabetes by understanding how bariatric surgery cures or improves this condition.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Diabetes Mellitus Typ 2 and Obesity

Interventions

ModifastDIETARY_SUPPLEMENT

2 weeks before gastric by-pass patients are treated with VLD, 1000 kcal/day

Normal dietDIETARY_SUPPLEMENT

normal diet 2 weeks before gastric by-pass

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diabetes typ 2 * 18-70 years * BMI \> 35 kg/m2 * Treated with oral antidiabetic agents and/or insulin * laparoscopic surgery Exclusion Criteria: * Pharmacological treatment (other then above) witch could affect glucose metabolism * open surgery

Locations (2)

Karolinska Institutet

Stockholm, Stockholm County Council, Sweden

Uppsala University Hospital

Uppsala, Sweden

Outcomes

Primary Outcomes

Insulin sensitivity

Insulin sensitivity measured by hyperinsulinemic normoglycemic clamp technique

Time frame: 12-18 month after gastric bypass

Secondary Outcomes

Weight reduction

Time frame: 12-18 month after gastric bypass

Data from ClinicalTrials.gov

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