Feasibility Study: Heavy Water Tissue Labeling Protocol

Inclusion Criteria: * Male or female, age 30 to 65 years scheduled for rhytidectomy. * Subject in good health. * Understands and accepts the obligation not to undergo any other procedures in the areas to be treated. * Willingness and ability to comply with protocol requirements, including returning for follow-up visits and abstaining from exclusionary procedures for the duration of the study. * Subjects of childbearing potential must have a negative urine pregnancy test result and must not be lactating at Visit 1 and be willing and able to use an acceptable method of birth control. * Absence of physical or psychological conditions unacceptable to the investigator. * Willingness and ability to provide written consent for study-required photography and adherence to photography procedures (i.e., removal of jewelry and makeup). * Willingness and ability to provide written informed consent and HIPAA authorization prior to performance of any study-related procedure. Exclusion Criteria: * Presence of an active systemic or local skin disease that may affect wound healing. * Severe solar elastosis. * Significant scarring in areas to be treated. * Open wounds or lesions in the area to be treated. * Severe or cystic acne on the area to be treated. * Presence of a metal stent or implant in the facial area to be treated. * Inability to understand the protocol or to give informed consent. * Microdermabrasion, or prescription level glycolic acid treatments to the submental area within two weeks prior to study participation or during the study. * Excessive dermatochalasis, deep dermal scarring, or thick sebaceous skin in the area to be treated. * BMI equal to or greater than 30.