The purpose of this study is to evaluate the effect of intraoperative administration of low-dose adrenaline on intraoperative blood loss in patients undergoing hip surgery.
Hip arthroplasty is associated with bleeding, anemia and the need for allogeneic transfusion. Administration of low-dose adrenaline activates the coagulation system and may decrease intraoperative and immediate postoperative bleeding. Thus, the aim of this study is to evaluation whether intraoperative IV-administration of low-dose adrenaline reduces bleeding in elective total hip arthroplasty.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
106
Adrenaline infusion 0.05 microgram / kg / minute
Intraoperative isotonic saline infusion as placebo for adrenaline.
Gentofte Hospital, Department of Anaesthesia
Hellerup, Denmark
Hvidovre Hospital, Department of orthopaedic surgery
Hvidovre, Denmark
Vejle Sygehus, Department of orthopedic surgery
Vejle, Denmark
Intraoperative blood loss
Intraoperative blood loss as estimated from surgical drain and sponges.
Time frame: End of surgery (last suture)
Calculated blood loss
Calculated blood loss at 24 h after end of surgery.
Time frame: 24 hours after end of surgery.
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