This is a pilot cohort study of women undergoing focal ablation for high-grade cervical intraepithelial neoplasia (HGCIN). The cohort was recruited from the UCSF Dysplasia Clinics. The standard treatment involves treatment of the entire cervix. Women with HGCIN meeting inclusion criteria were recruited for enrollment into the pilot study of focal treatment. Upon enrollment, they underwent focal ablational treatment rather than standard ablational treatment of the cervix. Follow-up visits were conducted at 2 weeks and 6 months to assess safety, feasibility, and acceptability. The 6-month recurrence rate of HGCIN will be calculated.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Focal treatment of high-grade cervical intraepithelial neoplasia using laser ablation, cryotherapy, or loop electrosurgical excision procedure
University of California, San Francisco
San Francisco, California, United States
Six-month recurrence rate of high-grade cervical intraepithelial neoplasia
Time frame: six months
Safety of focal treatment
Participants will be asked to report any adverse events following focal treatment. These events will be graded according to standard criteria (DAIDS).
Time frame: six months
Acceptability of focal treatment
Participants will be asked to respond to a survey at enrollment and follow-up asking whether they are satisfied with focal treatment as an alternative method of treatment.
Time frame: six months
Feasibility of focal treatment
Providers will be asked to provide information after each treatment regarding whether the treatment was technically feasible to perform.
Time frame: enrollment
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