The Safety & Efficacy of Intravitreal Aflibercept Injection in Patients With Persistent Central Serous Chorioretinopathy

Inclusion Criteria: * Pre-treatment acuity of 20/40- 20/320 * Macular fluid on optical coherence tomography for greater than 3 months * Leakage on fluorescein angiography * Willing and able to comply with clinic visits and study-related procedures * Provide signed informed consent Exclusion Criteria: * Treatment for CSCR in the study eye (anti-VEGF, PDT, or laser) within three months prior to study enrollment * Presence of choroidal neovascularization on enrollment imaging * Prior vitrectomy in the study eye * Presence of any substantial ocular disease (other than CSCR) that may compromise vision in the study eye and /or confound interpretation of the data; e.g. substantial cataracts, advanced glaucoma, optic neuritis, optic neuropathy or atrophy, marked macular atrophy, ocular vascular occlusion, history of retinal detachment, uveitis, viral or other forms of chorioretinitis, etc. * History of rhegmatogenous retinal detachment or macular hole (Stage 3 or 4) in the study eye * Uncontrolled glaucoma in the study eye (defined as IOP ≥ 25 mmHg despite treatment with anti-glaucoma medication) * Active ocular infection or inflammation in the study eye * Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either eye * Prior treatment with systemic anti-VEGF agents * Cerebrovascular accident or myocardial infarction within the preceding 6 months. * History of allergy to fluorescein, povidone iodine (Betadine) or aflibercept * Participation in a study of an investigational drug or device within 30 days prior to potential enrollment into the study * Pregnant or breast-feeding women Sexually active men\* or women of childbearing potential\*\* who are unwilling to practice adequate contraception during the study (adequate contraceptive measures include stable use of oral contraceptives or other prescription pharmaceutical contraceptives for 2 or more menstrual cycles prior to screening; intrauterine device \[IUD\]; bilateral tubal ligation; vasectomy; condom plus contraceptive sponge, foam, or jelly, or diaphragm plus contraceptive sponge, foam, or jelly) * Contraception is not required for men with documented vasectomy. * Postmenopausal women must be amenorrheic for at least 12 months in order not to be considered of child bearing potential. Pregnancy testing and contraception are not required for women with documented hysterectomy or tubal ligation.