Quantitative 18F-AV-133 PET Imaging in Subjects With Diabetes and Healthy Controls

Inclusion Criteria: * Male and/or female subjects of non-childbearing potential between the ages of 30 and 65 years inclusive. * Able to tolerate PET, PET/CT and MR imaging * Estimated creatinine clearance \>= 60mL/min * Informed consent documents signed and dated by subject * Subjects must be willing and able to comply with all scheduled visits, treatments laboratory tests, scans and other study procedures. * In addition, subjects must meet classification requirements for one of the following 1. Healthy Overweight 2. Pre-diabetes 3. T2DM * (T2DM only) Subjects with other chronic medical conditions (besides diabetes) that are well controlled and stable on medication are acceptable for inclusion in this study. Exclusion Criteria: * Subjects who are affiliated with or relatives of staff members of either the site or Pfizer directly involved in the conduct of the trial. * Conditions which in the opinion of the study investigator may interfere with the subject's ability to participate in the study * History of allergic reaction to drug/contrast agent or history of drug/alcohol abuse * Subjects who have received investigational medications within the last 30 days or a radiopharmaceutical in the past 7 days. * Pregnant or nursing females; females of childbearing potential.