Comparison Between Levofloxacin and Prulifloxacin, in Internal Medicine Patients With Acute Exacerbation of COPD

Inclusion Criteria: * \- Presence of purulent sputum documented by colorimetric assay (Allegra et al., Resp Med 2005), plus at least two of the following signs-symptoms * Increased cough * Increased dyspnea * Increase in sputum volume appeared at least 3 days * previous antibiotic treatment with any medication (eg, amoxicillin, amoxicillin / clavulanate, cephalosporins or macrolides) with the exception of quinolones, conducted for at least 3 days with persistence or worsening of symptoms and subsequent use of hospital * ≥ 60 years * FEV1 \<80% and ≥ 30% and ratio FEV 1 / FVC \<70% * chest x-ray negative for inflammatory infiltrates * informed consent Exclusion Criteria: * asthma * pulmonary neoplasms * a history of allergy or hypersensitivity to quinolones * impracticability in oral antibiotic and / or altered ability to absorption by the gastrointestinal system * a history of epilepsy, seizures, cerebral vascular disease (stroke cerebri within 6 months) * history of tendinopathy * note or severe renal impairment creatinine\> than twice the upper limit of the normal range or hepatic impairment (AST and / or ALT\> twice the upper limit of the normal range) * patients with sepsis, tuberculosis or other infections in other organs or systems * cystic fibrosis * patients with inherited tolerance to intolerance, Lapp lactase deficiency or glucose-galactose malabsorption, or deficiency of the enzyme glucose-6-phosphate dehydrogenase * pregnant or breastfeeding * drug or alcohol addiction * experimental concomitant treatment with other drugs