Androgen Deprivation Therapy (ADT) is standard treatment for locally advanced or advanced Prostate Cancer (PC). The musculoskeletal toxicity associated with ADT is well established, leading to a decrease in muscle mass, increased fat percentage, weight gain, sexual dysfunction and increased risk of depression, fatigue, diabetes, cardiovascular disease and reduced quality of life. Numerous studies have shown an association between physical activity, physical capacity and quality of life in cancer patients and recent epidemiological research suggest that regular, moderate-intensity physical activity may have a positive effect on survival in men with prostate cancer. Within exercise physiology there is new evidence pointing to recreational soccer as a unique form of intermittent exercise that effectively stimulates aerobic and anaerobic energy delivery systems, leading to beneficial musculoskeletal, metabolic and cardiovascular adaptations of importance for health. It is our overall hypothesis that 12 weeks of recreational soccer training 2-3 times per week will improve the health profile of PC patients receiving ADT treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
57
University of Copenhagen, Centre of Integrated Rehabilitation of Cancer Patients
Copenhagen, Copenhagen, Denmark
Baseline to post intervention (12 weeks) and follow-up (32 weeks) change in Body Composition.
Changes in body composition assessed by Dual-energy X-ray absorptiometry(DXA)scan
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
Bone Mineral Density
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
Cardiorespiratory fitness (Vo2 peak)
Change in maximal oxygen consumption (Vo2 peak) assessed directly during an incremental test on a cycle ergometer from baseline to post-intervention (12 weeks) and follow-up (32 weeks).
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
Patient reported outcomes
Changes in Psychological distress (Hospital Anxiety and Depression Scale, HADS), Quality of Life (EORTC QLQ C-30), general well-being (SF-36), disease specific symptoms and side-effects (EORTC PR-25)from baseline to post-intervention (12 weeks) and follow-up (32 weeks)
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
Heart function
Changes in Heart function measured by Echocardiography from baseline to post-intervention (12 weeks) and follow-up (32 weeks)
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
Glucose tolerance
Oral Glucose Tolerance Test
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
Postural Balance
Assessed standing on a force platform with feet in bilateral, unilateral and tandem position. Additionally assessed with a modified Flamingo balance test.
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
Physical function
Physical function will be assessed with sit to stand test (30s), stair climbing test and Counter Movement Jump (jump height)
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
Hip to waist ratio
Hip and waist circumference will be measured and the hip to waist ratio will be calculated
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
Muscle Strength
Muscle strength will be assessed with the 1Repetition Maximum test for knee extensors
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
Blood markers
Markers of inflammation and bone metabolism will be obtained after overnight fasting
Time frame: Change from baseline to post intervention (12 weeks) and follow-up (32 weeks)
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