Recent experimental and clinical studies have shown that platelets play a critical role in liver ischemia and regeneration. Thrombocytopenia, a frequent and potentially serious condition in liver transplantation (LT) recipients, was shown to be associated with postoperative morbidity and mortality after partial hepatectomy. The investigators aim at evaluating whether postoperative low platelet counts are indicators of short- and long-term outcomes after liver transplantation.
Study Type
OBSERVATIONAL
Enrollment
250
Standardized technique of liver transplantation Organ procurement follow the rules of the Swiss transplant society
University Hospital Zurich, Department of Visceral Surgery and Transplantation
Zurich, Canton of Zurich, Switzerland
Severe complication after liver transplantation
The severity of complications will be graded according to the Clavien-Dindo classification by outcome. Grade III to V complications will be considered as severe.
Time frame: 90 days
Primary graft non-function
Defined as death or retransplantation within the first postoperative week after exclusion of technical, immunological, and infectious causes
Time frame: first postoperative week
Delayed graft function
Defined as the presence of at least one of the following parameter at 7 days after LT: serum bilirubin \> 10 mg/dL and International Normalized Ratio (INR) \>1.6 or Alanine aminotransferase serum level (ALT) \>2000UI/L
Time frame: 7 days after liver transplantation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.