Effects of Colloid and Crystalloid on the Microcirculatory Alterations During Off-pump Coronary Artery Bypass Surgery

Seoul National University Hospital120 enrolled

Overview

The purpose of this study is to compare the effects of crystalloid and colloid, which are used for pump priming solution, on the microcirculatory alterations during cardiac surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

120

Conditions

Cardiac Surgery

Interventions

plasmalyte solutionDRUG

plasmalyte solution

HextendDRUG

Hetastarch administration instead of crystalloids until the total amount given reached 20 ml/kg, which is the maximally allowed daily dose. Afterward, plasmalyte solution infusion to meet the fluid requirements.

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Off-pump Coronary Artery Bypass Surgery Exclusion Criteria: * Infection * Postoperative use of steroid * Liver cirrhosis, Child-Pugh C * Renal disease on hemodialysis * Patients who cannot receive vascular occlusion test (severe peripheral vascular disease, arteriovenous fistula, burn) * EF \< 40% on the preoperative echocardiography * Preoperative use of vasopressors or inotropic agents

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Recovery slope

Recovery slope is a marker of microcirculation. The tissue oxygen saturation (StO2) using InspectraTM StO2 (Hutchinson Technology Inc.,USA) will be recorded continuously. The InspectraTM StO2 probe will be placed on the skin of the thenar eminence and the blood pressure cuff will be wrapped around the arm. After performing vascular occlusion test, the recovery slope will be calculated by the software.