Drug Delivery Via Pressurized Metered-dose Inhaler and Valved Holding Chamber in Asthmatic Children: Determination of Delivered Dose Following Coordinated and Uncoordinated Use

Inclusion Criteria: * • Asthmatic children between the ages of 5 and 8 followed at Arkansas Children's Hospital. * The subjects must be available to complete the study. * The subject's parent(s) and/or the subject's legal guardian must provide written informed consent to participate in the study. * The subject must provide assent when older than 7 years old. * The subjects should have used a pMDI VHC previously and be able to use a VHC with mouthpiece. * The subjects should have been prescribed fluticasone or another inhaled corticosteroid delivered via a pMDI VHC combination. * Clinically stable asthma. * Cooperative, i.e., subject should be able to follow and understand instructions. * The subject must satisfy the study investigator about his/her fitness to participate in the study. Exclusion Criteria: * Clinically significant respiratory disease in the previous 4 weeks. * Participation in any other clinical trial in the previous 4 weeks. * Lack of cooperation, subject cannot follow and understand instructions.