Nerve Transfer surgery can provide improved hand function following cervical spinal cord injuries
Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment options that provide meaningful improvements in patient quality of life and long-term functional independence will provide a significant public health impact. Specific Aim: Measure the efficacy of nerve transfer surgery in the treatment of patients with complete cervical spinal cord injuries with no hand function. Optimize the efficiency of nerve transfer surgery by evaluating patient outcomes in relation to patient selection and optimal timing the the surgery. Hypothesis: Peripheral nerve transfers in patients with spinal cord injuries will improve hand function and provide improvement in patient quality of life and functional independence.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
A nerve transfer procedure will be individualized to each patient's functional deficit.
Washington University
St Louis, Missouri, United States
Change in upper motor strength
Patients motor strength will be assessed over 48 months of clinical follow-up with conventional manual motor testing
Time frame: 48 months
Change in Disabilities of Arm, Shoulder, and Hand (DASH) scores
The change in DASH scores will be followed over time and assessed pre-operatively, 6,12, 18, 24, 36 and 48 months post-operatively.
Time frame: 48 months
Change in Short Form 36 (SF-36) scores
The change in SF-36 scores will be followed over time and assessed pre-operatively, 6, 12, 18, 24. 36 and 48 months post-operatively.
Time frame: 48 months
Change in Michigan Hand Questionnaire (MHQ)
The change in MHQ will be followed over time and assessed pre-operatively, 6, 12, 18, 24, 36 and 48 months post-operatively.
Time frame: 48 months
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