Blood cardiac troponin T (cTnT) concentration is a widely used marker of acute cardiac injury. Previous research has shown that type 2 diabetic patients may experience large increments in cTnT levels over the subsequent hours following a single bout of moderate-intensity endurance-type exercise. This phenomenon is likely attributed to cardiac ischemia-reperfusion injury caused by reduced nitric oxide (NO) bioavailability. Recent evidence indicates that ingestion of dietary nitrates dramatically increases the bioavailability of NO, and as such, may be protective against cardiac ischemia-reperfusion injury. The investigators hypothesize that dietary nitrate supplementation blunts the rise in cTnT levels following exercise in type 2 diabetic patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
10
ingestion of single dose NaNO3 beverage two hours prior to exercise bout
ingestion of single dose NaCl beverage two hours prior to exercise bout
Maastricht UMC
Maastricht, Netherlands
RECRUITINGCardiac troponin T
Cardiac troponin T levels will be assessed before exercise and over the 6-hour period following a single session of exercise.
Time frame: 9 hours, hourly time intervals
Plasma nitrate
Cardiac troponin T levels will be assessed before exercise and over the 6-hour period following a single session of exercise.
Time frame: 9 hours, hourly time intervals
Plasma nitrite
Plasma nitrite levels will be assessed before exercise and over the 6-hour period following a single session of exercise.
Time frame: 9 hours, hourly time intervals
Blood pressure
Blood pressure will be measured various time during the day.
Time frame: day
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