Safety Study of Anti LewisY Chimeric Antigen Receptor in Myeloma, Acute Myeloid Leukemia or Myelodysplastic Syndrome

Inclusion Criteria: * Applicable to all Patients * Patient is able to undergo apheresis of peripheral blood mononuclear cells (PBMC) within eight weeks following registration. * White cell count (WCC) \<30/nL as higher WCC could interfere with the apheresis of PBMC. * Patient has an ECOG performance status of 0 - 1. * Patient is deemed capable of undergoing the planned study procedures * Patient has adequate organ function: * bilirubin \<1.5x upper limit of normal (ULN), AST/ALT ≤2.5 x ULN except in patients with Gilbert's syndrome * Serum Creatinine \< 1.5 ×ULN or creatinine clearance \> 50ml/min * Amylase, lipase ≤1.5xULN * Lymphocyte count of ≥0.5x109/L * \> 18 years of age. * Patient has provided written informed consent. * No chemotherapy or treatment with G-CSF within 4 weeks prior to the planned apheresis. * Applicable to patients with multiple myeloma * Patient has histologically or cytologically confirmed diagnosis of multiple myeloma plus one or more of the criteria set out below must apply: * Presence of the following features that are known to be associated with an adverse prognosis with conventional chemotherapy, high-dose chemotherapy and autologous stem cell transplant (AUSCT): Chromosomal abnormalities: * 13q deletion * 17p deletion as p53-deletion by IHC on the bm trephine * Translocation (4:14) * Translocation (14:16) Clinical features: * Progressive disease within 12 months after previous AUSCT * Plasmablastic morphology * Plasma cell leukaemia * Patient planned for high-dose melphalan chemotherapy with AUSCT having had at least two prior treatment regimens (which can include prior high-dose chemotherapy and AUSCT and must include at least one of thalidomide, lenalidomide or bortezomib). * Patient has previously proven LewisY expression on the plasma cells prior to study entry in an analysis as defined in study criteria * Patient is planned to receive high dose melphalan and autograft (after apheresis of PBMC) * Additional inclusion Criteria applied to patients with acute myeloid leukaemia (AML)/high-risk myelodysplastic syndrome (MDS) All of the following must apply: * Patient must either have newly diagnosed AML/high-risk MDS with a poor prognosis or relapsed/refractory AML/high-risk MDS * Patient has previously proven LewisY expression on the myeloblasts prior to study entry in an analysis as defined in study criteria * Patient is planned to receive fludarabine containing regime (FCR) chemotherapy (after apheresis of PBMC) which is planned to be the last cycle of FCR chemotherapy, no further FCR chemotherapy should be planned within 3 months after this cycle of FCR Definition of poor prognosis in AML/high-risk MDS A patient with AML has a poor prognosis if any of the following is satisfied: * Age \> 65 years * Age 56 - 65 years with any of the following single cytogenetic abnormalities: -7, -5, trisomy 8, abnormal 3q, t(6;9), t(9;22) or t(9;11), normal karyotype with FLT3-ITD * Age 56 - 65 years with a complex aberrant karyotype defined as \>4 cytogenetic abnormalities * Any age with relapsed or refractory disease Exclusion Criteria None of the following should apply: * Patient has had immunotherapy including corticosteroids (except Prednisolone \<10mg or equivalent) within the last 4 weeks or is planned to receive such therapy prior to apheresis of PBMC. * Patient has been given chemotherapy and/or G-CSF in the last 4 weeks. * Patient has been planned to receive chemotherapy and/or growth factors of any type before planned apheresis of PBMC * Patient has been given experimental therapy within the last 4 weeks or is planned to receive experimental therapy prior to apheresis of PBMC * Patient has known clinically significant autoimmune disease with positive serology for RHF (\>20kU/L) or ANA (titre \>1:40) * Patient has a history of idiopathic pancreatitis Patient has known, biopsy proven autoimmune inflammatory disease of the gastrointestinal tract * Women of child bearing potential (WOCBP) who are unwilling or unable to use an effective method of contraception to avoid pregnancy for the entire study period and for at least 3 months after completion of study treatment. * Women who are pregnant or breastfeeding. * Men who are unwilling or unable to use an acceptable method of contraception for the entire study period and for at least 3 months after completion of study treatment if their sexual partners are WOCBP. * Patient has known central nervous system (CNS) disease. * Patient has a serious uncontrolled medical disorder which would impair the ability to receive protocol therapy.