Clinical Study of Metronomic Oral Cyclophosphamide in Patients With Advanced Sarcomas

Inclusion Criteria: Participants must meet the following criteria on screening examination to be eligible to participate in the study: 1. Participants must have histologically or cytologically confirmed, metastatic and/or unresectable high grade sarcoma for which standard multi-modality curative therapies do not exist or are no longer effective. Patients with low grade sarcoma need to additionally demonstrate disease progression in the last 6 months prior to study entry. 2. Age \> 21 years 3. Prior anti-sarcoma chemotherapy * Participants who are 21 to 64 years of age at the time of study entry must have received at least one line of established chemotherapy, if such treatment exists; or refused such treatment, which includes either an anthracycline and/or ifosfamide. Patients whose sarcomas do not have known established therapy are eligible for this study without the requirement of a prior therapy. * Participants \> 65 years of age at the time of study entry are eligible for this study without the requirement for prior treatment 4. ECOG performance status 0-3 (see Annex A) 5. Measurable disease outside of a prior irradiated area as defined by RECIST 1.1 guidelines. A lesion in a previously irradiated area is not eligible for measurable disease unless there is objective evidence of progression of the lesion prior to study enrollment 6. No limit to number of prior chemotherapies or biologics 7. Participants must have normal organ function as defined below: * Hemoglobin \> 10g/dL * Absolute neutrophil count (ANC) \> 1500/mm3 * Platelet count \> 75,000/mm3 * Total bilirubin \< 1.5 times institutional upper limits or normal (ULN) * AST/ALT \< 3 times ULN (\< 5 times ULN if hepatic involvement is present) * Creatinine \< 1.5 times ULN. If creatinine is \> 1.5 times ULN, a calculated creatinine clearance time (CCT) should be performed and patient would be eligible for study if the calculated CCT is \> 10 mL/min. \[NB: Glomerular filtration rate (GFR) = \[(140 - age) x weight \[kg\] x 1.22 \] / (serum creatinine \[umol/L\]. In women, multiply this result by 0.85 8. Resolution, or return to baseline of all clinically significant toxicities related to prior therapies 9. Patients must be suitable for oral drug administration 10. Willingness to use effective means of birth control throughout the duration of clinical study and for at least 3 months after completion of study drug 11. Women of childbearing potential must have a negative pregnancy test performed within 7 days of the start of study drug administration 12. Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: Participants who exhibit any of the following conditions at screening will not be eligible for admission into the study. 1. Patients diagnosed with gastrointestinal stromal tumor (GIST) 2. Participants who have had systemic anti-cancer therapy within 3 weeks of study entry (8 weeks for nitrosoureas or mitomycin C) 3. Palliative radiotherapy or major surgery within 3 weeks of study entry 4. Concurrent use of any other anti-cancer therapies or study agents 5. Symptomatic or uncontrolled brain or central nervous system metastases 6. Participants may not be receiving any other concomitant investigational agents 7. Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements 8. Individuals with a history of a different malignancy, other than cervical cancer in situ, basal cell or squamous cell carcinoma of the skin, are ineligible, except if they have been disease-free for at least 5 years, and are deemed by the investigator to be at low risk for recurrence of that malignancy OR other primary malignancy is neither currently clinically significant nor requiring active intervention.