The Effects of Puberty and Weight on Sugar Metabolism in Children

Baylor College of Medicine83 enrolled

Overview

Our goal is to investigate how hormones that control blood sugar, hunger, and stomach emptying change with puberty and being overweight. These substances change with a meal. * For this, we need to compare lean and overweight children. * We need to study them before and during puberty. * All children in the study will be tested before and after a liquid meal.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Overweight Leanness Adolescent

Eligibility

Sex: ALLMin age: 8 YearsMax age: 17 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: All groups: Healthy lean and otherwise healthy overweight children and adolescents between the ages of 8 and 17. Exclusion Criteria: Same for all groups The subjects will be excluded if they have: * a history of chronic disease * allergy to acetaminophen * evidence or history of chemical abuse * abnormal lab values * pregnancy

Locations (1)

Baylor College of Medicine

Houston, Texas, United States

Outcomes

Primary Outcomes

Overweight and Lean Children Sugar Metabolism Before and During Puberty

Too much weight gain can cause changes in the substances that control blood sugar and hunger in the body. Scientists need to compare these substances in lean and overweight children before and during puberty. These substances can be measured before and after a meal in the blood and in the urine. The way your stomach moves food can change your sugar levels. We want to understand how diabetes develops by studying these things. This can help find better ways to prevent and treat diabetes.

Time frame: 4 hours

Data from ClinicalTrials.gov

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