the purpose of this study is to investigate the development of insulin resistance in multiple sclerosis patients + explaining the effects of a combined training programme on insulin resistance, muscle power and aerobic capacity in multiple sclerosis patients
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
45
REVAL
Diepenbeek, Belgium
insulin sensitivity (insulin profile)
glucose and insulin concentration measurements in blood
Time frame: change from baseline to 24 weeks
aerobic capacity
by means of a submaximal endurance test (ergometer)
Time frame: change from baseline to 24 weeks
aerobic capacity - lactate concentrations
by means of a submaximal endurance test (ergometer) to determine lactate concentrations (mmol/L)
Time frame: change from baseline to 24 weeks
cytokine profile
measurements of blood cytokine levels
Time frame: change from baseline to 24 weeks
walking performance
Walking performance will be assessed by means of 2 and 6 minute walk test, 25-foot walk test, Chair rise test, Stair climb test
Time frame: change from baseline to 24 weeks
Self-reported measures
The self-reported measures contains some questionnaires
Time frame: Change from baseline to 24 weeks
body composition
Weight, body fat% and lean tissue% will be assessed by means of a DEXA (Dual-energy X-ray absorptiometry) scan
Time frame: Change from baseline to 24 weeks
muscle strength of knee flexor
by means of an isokinetic dynamometer the muscle strength and endurance will be measured
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Time frame: change from baseline to 24 weeks
muscle strength of knee extensor
by means of an isokinetic dynamometer the muscle strength and endurance will be measured
Time frame: change from baseline to 24 weeks
muscle strength of elbow flexor
by means of an isokinetic dynamometer the muscle strength will be measured
Time frame: change from baseline to 24 weeks
muscle strength of elbow extensor
by means of an isokinetic dynamometer the muscle strength will be measured
Time frame: change from baseline to 24 weeks