The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation Under Propofol-remifentanil Anesthesia in Elderly Patients

N/ACompletedNCT01720498

Severance Hospital50 enrolled

Overview

To find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients

The increase of Corrected QT (QTc) interval is associated with age. It is known that most inhalation anesthetics or intravenous anesthetics can influence the QTc. In addition, tracheal intubation during induction can stimulates sympathetic activity, which, as a results, prolong the QTc interval. Therefore, the aim of study is to find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

General Surgery With Endotracheal Intubation

Interventions

remifentanilDRUG

The effect site concentration of remifentanil

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ≥ 65 years ASA class I-II who received surgery with endotracheal intubation Exclusion Criteria: * emergency surgery * electrocardiography abnormality * hypertension * diabetes mellitus * end stage renal disease * moderate to severe cardiac disease * moderate to severe liver dysfunction

Locations (1)

Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine

Seoul, South Korea

Outcomes

Primary Outcomes

The effect site concentration for preventing QTc interval prolongation

Time frame: 2 min

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.