Effect of Dietary Fat Cooking Blend on Energy Expenditure in Children

N/ACompletedNCT01720589

St. Luke's-Roosevelt Hospital Center5 enrolled

Overview

The purpose of this study is to test the effects of a cooking oil blend of dietary fats rich in medium chain triglycerides on energy expenditure and food intake in overweight and obese children.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Childhood Obesity

Interventions

Melt (test oil)DIETARY_SUPPLEMENT

Corn oil (control)DIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 15 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 15-18 * body mass index 85% percentile or higher for age/sex * weight stable Exclusion Criteria: * ±5 lbs weight change in the the 3 months prior * use of medications * dietary allergies * metabolic disorder * eating disorder * behavioral or psychological disorders

Locations (1)

St. Luke's/Roosevelt Hospital

New York, New York, United States

Outcomes

Primary Outcomes

Thermic effect of food

Measurement of thermic effect of food over 6 hours after a meal rich in test oil and control oil. The thermic effect of food is the difference between post-prandial energy expenditure and basal energy expenditure. We will assess the difference in thermic effect of food over a 6-hour period between the test oil and the control oil.

Time frame: 6 h

Respiratory quotient/fat oxidation

Measurement of substrate oxidation by indirect calorimetry over 6 hours after consumption of the test oil and control oil. We will specifically calculate carbohydrate and fat oxidation rates over the 6-hour period post-prandially and compare rates of oxidation of these two substrates between the test oil and the control oil.

Time frame: 6 h

Food intake

Measurement of food intake at a single meal served 1 hour after a pre-load containing 8-10 g of the test oil and the control oil

Time frame: single meal

Secondary Outcomes

Glucose

Measurement of glucose over 6 hours after consumption of the test oil and control oil

Time frame: 6 h

Feelings of appetite and satiety

Measurement of feelings of appetite and satiety by visual analog scales over 6 hours after consumption of the test oil and control oil

Time frame: 6 h

Insulin

Measurement of insulin over 6 hours after consumption of the test oil and control oil

Time frame: 6 hours

Leptin

Measurement of leptin over 6 hours after consumption of the test oil and control oil

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.