Migraine and Body Composition

N/ACompletedNCT01720862

Johns Hopkins University300 enrolled

Overview

This research is being done to look at the association between migraine and obesity.

Research into the role of inflammatory markers and other obesity related proteins and chemicals may help us understand migraine and lead to new treatment.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Migraine With and Without Aura Chronic Migraine Healthy Controls

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Premenopausal women (18-55 years) * Normal weight (BMI = 18.5 - 24.9) or obese (BMI ≥ 30) * Diagnosis of episodic or chronic migraine or pain free control Exclusion Criteria: * Evidence of pain disorder other than migraine (e.g. irritable bowel syndrome) * Chronic conditions known to alter risk or pattern of migraine (e.g. hypothyroidism) * Illnesses that may affect adipokine levels (e.g. diabetes) * Clinically relevant abnormal glucose/cholesterol levels * Pregnant women * Potential participants who are unable to undergo MRI based on standard screening questionnaire (those with brain aneurysm or surgical clips, certain types of artificial heart valves, heart defibrillator or pacemaker, cochlear implants, eye implants, blood vessel coil, recently placed artificial joints, certain types of vascular stents, history of bullets, pellets, BBs, history of any implanted metal or device or who have worked with sheet metal in the past)

Locations (1)

The Johns Hopkins Bayview Headache Center

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

association between migraine and obesity - evaluate serum adipokine levels

The first aim of the proposed research is to evaluate serum adipokine levels in a clinical cohort of obese and non-obese episodic and chronic migraineurs and examine their utility as markers of the presence or absence of migraine and their relationship to headache frequency.

Time frame: 5 years

Secondary Outcomes

association between migraine and obesity -evaluate subcutaneous adipose tissue (SAT) and its ratio to visceral adipose tissue (VAT)

The second aim of the proposed research is to evaluate subcutaneous adipose tissue (SAT) and its ratio to visceral adipose tissue (VAT),in the same clinical cohort of migraineurs to determine if regional adipose tissue differences exist between: (1) episodic migraineurs, (2) chronic migraineurs and (3) controls, thus contributing to the migraine-obesity relationship.

Time frame: five years

Data from ClinicalTrials.gov

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