Reducing Nephrotoxicity of Vancomycin: A Prospective Study of Continuous Versus Intermittent Infusion of Vancomycin

N/AUnknownNCT01720940

National University Hospital, Singapore220 enrolled

Overview

This study is being carried out to find out whether there is reduction in vancomycin-induced kidney injury (nephrotoxicity) when vancomycin is given as intermittent versus continuous infusion. This study will recruit 220 subjects from 2 hospitals over a period of 3 years. Participants are invited if they have an infection that requires prolonged vancomycin therapy (\> more than 10 days).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

220

Conditions

Infections Requiring Prolonged Duration (>10 Days) of Vancomycin

Interventions

continuous vancomycin infusionDRUG

24-hour continuous infusion of vancomycin

intermittent vancomycin infusionDRUG

Eligibility

Sex: ALLMin age: 21 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged 21-80 years * Documented infection requiring prolonged (\> 10 days) of vancomycin therapy * Creatinine clearance \> 50 ml/min (using Cockroft-Gault equation) Exclusion Criteria: * Patient already received 7 days or more of vancomycin therapy * Pregnancy * Severe burns \> 40% body surface area * Spinal cord injuries * Participation in another interventional trial in previous 30 days * Inability to obtain informed consent

Locations (1)

National University Hospital

Singapore, Singapore

RECRUITING

Outcomes

Primary Outcomes

nephrotoxicity

nephrotoxicity as defined by the acute kidney injury network (AKIN) criteria using only serum creatinine criteria

Time frame: occurring any time while on vancomycin treatment up to 14 days post treatment completion

Secondary Outcomes

biomarkers for detection of early nephrotoxicity

serum and urine NGAL and cystatin C

Time frame: measured weekly from the date of randomization until 14 days post completion of vancomycin

Central Contacts

Shire Yang Tan

CONTACT

97989001 shire_yang_tan@nuhs.edu.sg

Data from ClinicalTrials.gov

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