Safety and Efficacy Study of the Cardiapex Percutaneous Trans-apical Access and Closure System

Inclusion Criteria: * Patient scheduled for transapical TAVI * Patient ≥ 70 years of age * Patient able to give informed written consent * Patient able to attend follow up examinations Exclusion Criteria: * Scheduled concomitant non-TAVI cardiac procedure * Patient with Left Ventricular Ejection Fraction (LVEF) \< 30% at time of enrollment * Patient with known apical infarcted area * Patient with a distinct large vessel right at the anatomical apex9 (based on pre-operative coronary angiography * Patients with known lung tissue surrounding the apex and possibly interfering with the in-out puncture (based on preoperative gated CT assessment * Patient with contra-indications to transapical TAVI * Patient's inability to tolerate or comply with normal post-surgical drug regimen * Patient's inability to comply with required follow-ups, including echocardiography * Patient participation in other clinical trials within previous month