Abnormal vaginal flora is a risk factor for preterm labor. Therefore, in high risk pregnancies for preterm labor the diagnosis and treatment of abnormal flora is indicated. Clindamycin and metronidazole given orally are both acceptable treatments in these cases. The purpose of this study is to compare the effectiveness of Clindamycin Vs metronidazole for the treatment of abnormal vaginal flora in high risk pregnancies. For this purpose, pregnant women who are considered high risk for preterm labor and were diagnosed with abnormal vaginal flora will be randomly treated either with clindamycin or metronidazole. Eradication of the abnormal flora and adverse effects will be monitored and compared
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
166
Oral clindamycin 300 Milligrams\*2/Day for a week
Oral metronidazole 500 Milligrams\*2/Day for a week
Departement of obstetric and gynecology, Poriya Medical Center
Tiberias, Israel, Israel
Departement of obstetric and gynecology, HaEmek medical center
Afula, Israel
To compare the efficacy between oral Clindamycin Vs Metronidazole in the eradication of abnormal vaginal flora
Time frame: Primary outcome will be assessed by taking a vaginal culture sample a week after one-week antibacterial treatment
The prevalence of adverse effects
Time frame: During the antibacterial treatment which is 1 week of therapy
The prevalence of late abortions and preterm deliveries
Time frame: From date of randomization until the date of delivery or abortion, assessed up to 28 weeks
Assessing the correlation between Nugent score , physical examination and Ph indicators
Time frame: The outcome is assessed after the diagnosis of abnormal vaginal flora is made at 14-26 weeks of gestation
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