Transpulmonary Gradient After Cardiac Surgery Under Cardiopulmonary Bypass

University Hospital, Strasbourg, France30 enrolled

Overview

Get a better understanding of the pathophysiological processes of acute respiratory failure following cardiopulmonary bypass to initiate timely therapies targeted on a cell line. Demonstrate that there is a relationship between increased transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance on the one hand and alveolo-capillary gas exchange on the other hand after cardiac surgery under cardiopulmonary bypass.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Respiratory Distress Syndrome After Cardiac Surgery Under Cardiopulmonary Bypass

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient man or woman \> 18 y.o. * Patient has signed informed consent prior to the study * Patient affiliated to a social security administration * Patient operated on for cardiac surgery at the University Hospital of Strasbourg. * Patient at high risk for postoperative respiratory failure defined by a SLIP score (Kor et al.) ≥ 22 Kor: * High-risk cardiac intervention under cardiopulmonary bypass (19 pts) * COPD (10 pts) * Diabetes (6 pts) * gastroesophageal reflux (7 pts) * Alcohol abuse (11 pts) * Scheduled use of a pulmonary artery catheter and a left atrial catheter Exclusion Criteria: * Inability to obtain informed consent from the patient and / or unable to give informed patient information (difficulty understanding ...) * Urgent surgery (\<24h) * Acute heart failure * Patient ventilated preoperatively * Allergy to Latex * Persons deprived of liberty or under judicial protection * Patient placed under guardianship * Pregnancy * Breastfeeding

Locations (1)

University Hospital

Strasbourg, Alsace, France

Outcomes

Primary Outcomes

transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance

Demonstrate that there is a relationship between increased transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance on the one hand and alveolo-capillary gas exchange on the other hand after cardiac surgery under cardiopulmonary bypass.

Time frame: during the surgery

Central Contacts

Julien POTTECHER, MD

CONTACT

03 88 12 70 95 julien.pottecher@chru-strasbourg.fr

Data from ClinicalTrials.gov

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