Effectiveness of Testosterone Undecanoate to Improve Sexual Function in Postmenopausal Women

Chulalongkorn University70 enrolled

Overview

Additional testosterone undecanoate can improve female sexual function in postmenopausal women which one aspects of quality of life. The dose adjustment can reduce incidence of adverse effects and low cost of treatment with effective outcome.

Research Question: " Does oral testosterone undecanoate improve sexual problem in postmenopausal women? " Type Research:Clinical research Study design: Randomized double-blinded placebo controlled trial

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Female Sexual Dysfunction

Interventions

Testosterone undecanoateDRUG

testosterone undecanoate 40 mg orally twice a week

placeboDRUG

placebo orally twice a week with progynova 1 mg oral daily

Eligibility

Sex: FEMALEMin age: 40 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * postmenopausal women with age between 40-60 years * Women complain about her sexual problem and her score of Female Sexual Function Index ≤ 26.5 Exclusion Criteria: * women with previous use of hormonal replacement or anti-psychiatric drugs within 3 months * women with history of or present premalignancies/malignancies * women present with liver disease or abnormal liver enzyme * women with active cardiovascular, cerebrovascular or thromboembolic disorders * women with Present psychiatric disease * Partner have sexual dysfunction

Locations (1)

King Chulalongkorn memorial hospital

Bangkok, Bankok, Thailand

Outcomes

Primary Outcomes

female sexual function index score

Time frame: 8 weeks

Secondary Outcomes

adverse effects of the drug

1. weight gain 2. acne 3. hirsutism. 4. vaginal bleeding

Time frame: 8 week

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.