Comparison the Effects of Dexamethasone and Loteprednol on Epithelial Healing

Khon Kaen University32 enrolled

Overview

Corticosteroid has been used for the treatment after phototherapeutic keratectomy (PRK). Dexamethasone, a potent steroid can retard the corneal epithelial healing rate and has numerous serious complications, especially glaucoma. Loteprednol, a new generation of corticosteroid has less potency than dexamethasone and was proposed to has less side effect regarding intraocular pressure (IOP) elevation. Therefore, Investigators would like to compare the effect of dexamethasone and loteprednol on corneal epithelial healing rate after PRK and risk of glaucoma.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Epithelial Defect After Phototherapeutic Keratectomy

Interventions

DexamethasoneDRUG

Loteprednol etabonateDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * the patient with epithelial defect after phototherapeutic keratectomy Exclusion Criteria: * the patient with systemic disease such as diabetes and connective tissue disease * the patient with ocular surface disease such as dry eye and recurrent corneal erosion

Locations (2)

Onsiri Thanathanee

Khon Kaen, Changwat Khon Kaen, Thailand

Srinagarind Hospital

Khon Kaen, Changwat Khon Kaen, Thailand

Outcomes

Primary Outcomes

corneal epithelial healing

Time frame: 1 month

Secondary Outcomes

intraocular pressure

Time frame: 6 month

Data from ClinicalTrials.gov

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