Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management

China Medical University, China219 enrolled

Overview

We designed a study to determine whether a single dose of dexmedetomidine or thoracic epidural anesthesia combined with general anesthesia would provide hemodynamic stability, reduce stress hormone responses, inhibit inflammatory cytokine secretion, and improve sleep quality in patients after thoracic surgery.

We designed a prospective, single-blinded, randomized, and controlled study to determine whether a single dose of dexmedetomidine or thoracic epidural anesthesia combined with general anesthesia would provide hemodynamic stability, reduce stress hormone responses, inhibit inflammatory cytokine secretion, and improve sleep quality in patients after thoracic surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

219

Conditions

General Anesthesia, Thoracic Epidural Anesthesia

Interventions

general anesthesia combined with dexmedetomidine infusionDRUG

general anesthesia combined with 1 μg/kg dexmedetomidine infusion after induction (Group D)

general anesthesia combined with TEAPROCEDURE

general anesthesia combined with TEA (Group E)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * lung surgery * one-lung ventilation. Exclusion Criteria: * body mass index exceeding 30 kg/m2, * autonomic dysfunction, * cardiovascular disease, * neurological or psychiatric diseases

Locations (1)

Department of Anesthesiology, the First Hospital of China Medical University

Shenyang, Liaoning, China

Outcomes

Primary Outcomes

inflammatory cytokine secretion and postoperative sleep quality

Primary outcomes were inflammatory cytokine secretion and postoperative sleep quality, which was measured with the BIS data on first and second postoperative nights.

Time frame: immediately before anesthesia (T1), 5 min after endotracheal intubation (T2), immediately after incision (T3), 5 min after OLV initiation (T4), 5 min after double-lung ventilation initiation (T5), and immediately after extubation (T6)

Secondary Outcomes

amine secretion during the surgical period and hemodynamic stability

amine (epinephrine and norepinephrine) secretion during the surgical period and hemodynamic stability

Data from ClinicalTrials.gov

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