Transdermal Fentanyl Patch for Postoperative Analgesia After Abdominal Surgery: a Randomized Placebo-controlled Trial

Khon Kaen University50 enrolled

Overview

Abdominal surgery causes severe postoperative pain. Multi-modal pain therapy is usually applied but there is no perfect choice. It depends on physician's skill and situation. The best regimen is patient-controlled analgesia, but it requires an expensive equipment. Transdermal fentanyl patch, usually used in chronic pain relief, can steadily release fentanyl into blood stream for 72 hours, but it has slow onset of 12 hours. Hypothesis: If Transdermal fentanyl patch is applied 10-12 hours before surgery, it may provide good analgesia for 72 hours.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postoperative Pain Relief

Interventions

transdermal fentanyl patch (50 mcg/hour)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age =\>18 years * scheduled for abdominal surgery Exclusion Criteria: * ASA class \> 3 * Known allergy to fentanyl or morphine * History of substance or alcohol abuse, and tolerance or dependence on opioids * Combined epidural block * Can't use PCA, abnormal renal / liver function

Outcomes

Primary Outcomes

morphine consumption

Compare the cumulative morphine consumption during 24 hours postoperative of both study and control groups.

Time frame: 24 hours

Secondary Outcomes