Effect of Intravitreal Bevacizumab on Corneal Endothelium

Khon Kaen University37 enrolled

Overview

To evaluate corneal endothelium cell change after intravitreal Bevacizumab injection

Intravitreal Bevacizumab has been used by retinal specialist in treatment many retinal diseases. Although it not approved by FDA for treatment. In many In vitro studies, its showed saftey in the eyes especially for corneal endothelium cells, that important cells to keep cornea clear. This study use Confoscan-Corneal confocal microsope to evaluate corneal endothelium before and after intravitreal Bevacizumab injection in routine retinal disease at 6 month follow up.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Corneal Endothelial Cell Loss

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * aged between 20 and 80 years old * can come to regular follow up at 6 month * signed written consent forms * not have corneal scar, or glaucoma * history of treatment with laser or anti-VEGF therapy in 3 month prior to recruit * high risk in cerebrovascular and cardiovascular diseases * Pregnancy and breastfeeding * can undergo confocal microspopy Exclusion Criteria: * History of intraocular surgery or ocular trauma during study

Locations (1)

KKU eye center, department of Ophthalmolgy, faculty of medicine, khon kaen university

Khon Kaen, Changwat Khon Kaen, Thailand

RECRUITING

Outcomes

Primary Outcomes

Corneal endothelium cell change after intravitreal Bevacizumab injection

Measure the corneal endothelium cell using Confoscan4-Corneal confocal microscope in patient in retinal vascular clinic before and after treat with intravitreal Bevacizumab

Time frame: 6 months

Secondary Outcomes

Assess the complication after intravitreal Bevacizumab injection

Time frame: 6 month

Central Contacts

Kasem Yospaiboon, MD

CONTACT

66823057231 kasem_yod@hotmail.com

Data from ClinicalTrials.gov

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