NEFA (Non Esterified Fatty Acid) , Adipose Factors Behind Insulin Sensitivity

Karolinska Institutet500 enrolled

Overview

We want to asses the role of adipose tissue for metabolic complications to obesity before and after weight loss (surgery).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

500

Conditions

Obesity Non-obese Controls

Interventions

ObeseOTHER

gastric bypass

Control groupOTHER

Cholecystectomy and anti-reflux surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria obese: * Bariatric surgery with laparoscopic gastric by-pass Exclusion Criteria obese: * diabetes mellitus typ 2 with insulin treatment and/or glitazones * oral or parenteral steroid treatment * complicated psychiatric disease * Warfarin use Inclusion Criteria non-obese controls: * BMI under 30 Exclusion Criteria non-obese controls: * diabetes * oral or parenteral steroids treatment * complicated psychiatric disease * Warfarins use

Locations (3)

Ersta Hospital

Stockholm, Sweden

Karolinska University Hospital

Stockholm, Sweden

Danderyds Hospital

Stockholm, Sweden

Outcomes

Primary Outcomes

Insulin sensitivity, adipose tissue function and gene function

Performed with hyperinsulinemic euglycemic clamp before and two years after surgery. Subcutaneous and visceral fat biopsy at the time of surgery.

Time frame: two years after surgery

Secondary Outcomes

Body composition

DEXA (Dual-Energy X-ray absorptiometry), before and two years after surgery

Time frame: two years after surgery

Vascular function

Non invasive ultrasound of vascular stiffness, before and two years after surgery

Time frame: two years after surgery

Data from ClinicalTrials.gov

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