Inspiratory Muscle Training and Asthma

University of Portsmouth16 enrolled

Overview

This is a pilot study which will assess the feasibility of a follow on main study. This study will examine the impact of inspiratory muscle training on quality of life, rescue drug medication usage, and other markers of asthma in adult asthmatics in the UK.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Asthma

Interventions

inspiratory muscle trainingOTHER

Both groups will undertake six weeks of inspiratory muscle training (POWERbreathe, H\&B International Ltd, UK), six days per week, with the only difference being the load set on the inspiratory muscle training device. For the real inspiratory muscle training group this load will be set to around 50% of maximal inspiratory mouth pressure and for the sham inspiratory muscle training group this load will be set to around 5% of maximal inspiratory mouth pressure.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 59 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Asthma Control Questionnaire score of ≥ 1.5 * 10 mg or less of prednisolone (or equivalent) daily * Aged 18 to 59 years inclusive * Able to provide written informed consent Exclusion Criteria: * Any significant heart or lung disease other than asthma including any previous history of pneumothorax * Patients with a concomitant condition (including clinically relevant cardiovascular, hepatic, neurological, endocrine, or other major systemic disease) not controlled with treatment, making implementation of the protocol or interpretation of the study results difficult * Women who are pregnant * Forced expiratory volume in one second of less than 50% best or predicted * A history of smoking 20 cigarettes a day for 20 years or more (or an equivalent amount) * Undertaken a structured program of inspiratory muscle training within the past three months * Currently a participant in another interventional study

Locations (2)

Respiratory Centre, Queen Alexandra Hospital, Cosham

Portsmouth, Hampshire, United Kingdom

University of Portsmouth

Portsmouth, Hampshire, United Kingdom

Outcomes

Primary Outcomes

Maximal Inspiratory Mouth Pressure (MIP)

MIP is a surrogate measure of inspiratory muscle strength and was measured pre and post 6 weeks of either experimental or sham inspiratory muscle trianing (IMT).

Time frame: pre (after the 4 week run-in) and post 6 weeks of IMT

Data from ClinicalTrials.gov

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