Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.
Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion. Blood samples for concentration of metoprolol are taken preoperaively, 1. and 3. day after operation, before and 10 times after intake of 50 mg metoprolol. Sudy is randomized into 3 groups: 1. Miniperfusion n.15 2. Perfusion n.15 3. offpump n.15
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
45
measure blood concentration of metoprolol
Kuopio University Hospital
Kuopio, Kuopio, Finland
RECRUITINGabsorbtion of the metoprolol
absorbtion of the metoprolol, blood samples are taken centrifuged, frozed and analyzed
Time frame: one year
atrial fibrillation
is there correlation of incidence of the postopeative AF and absorbtion of the metoprolol
Time frame: one year
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