A Multicenter, Observational Study to Evaluate Clinical Manifestation, Diagnosis and Treatment of Primary Hemifacial Spasm in Chinese Patients

Peking Union Medical College Hospital1,003 enrolled

Overview

To determine the clinical manifestation, diagnosis and treatment options of primary hemifacial spasm in Chinese outpatient subjects

About 1000 outpatient subjects will be recruited. The inclusion criteria include clinically diagnosed primary hemifacial spasm, male or female 18 to 80 years old and informed consent has been obtained. The exclusion criteria include secondary hemifacial spasm, other involuntary facial movement disorder, history of surgery of microvascular decompression of the facial nerve and so on. The outcome measures include the percentage of the treatment methods of HFS in outpatient subjects, aggrevated and relieved factors of HFS symptom, concomitant symptoms of HFS and adverse events of botulinum toxin treatment in HFS patients.

Study Type

OBSERVATIONAL

Enrollment

1,003

Conditions

Hemifacial Spasm

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1.Clinically diagnosed primary hemifacial spasm 1. Tonic and clonic contractions of muscles innervated by the unilateral facial nerve. 2. No other neurological disorder. 2.Male or female 18 to 80 years old 3.Informed consent has been obtained Exclusion Criteria: 1. Secondary hemifacial spasm: brainstem tumor, surgery, facial neuritis and so on. 2. Other involuntary facial movement disorder: facial synkinesia after facial palsy, tics, myokymia and focal motor seizures. 3. History of surgery of microvascular decompression of the facial nerve. 4. Participation in another clinical study currently. 5. Not able to understand and answer questionnaire. 6. Investigator's opinion that the subject has a concurrent condition(s) that may confound the study results.

Locations (1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

The percentage of the treatment methods of HFS in outpatient subjects

Time frame: November, 2012

Secondary Outcomes

Distribution of onset age of hemifacial spasm patients

Time frame: November, 2012

Analysis of aggrevated and relieved factors of HFS symptom

Time frame: November, 2012

Analysis of concomitant symptoms of hemifacial spasm

Time frame: November, 2012

Adverse events of botulinum toxin treatment in hemifacial spasm

Time frame: November, 2012

Data from ClinicalTrials.gov

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