Dietary Interventions in Prediabetes

Mayo Clinic48 enrolled

Overview

Assessment of glucose metabolism and liver fat after 12 week dietary intervention in pre diabetes subjects. Subjects will be randomized to either high fat (olive oil supplemented),high carb/high fiber (beans supplemented) and high carb/low fiber diets. Glucose metabolism will be assessed by labeled oral glucose tolerance test and liver fat by magnetic resonance spectroscopy pre randomization and at 8 and 12 week after starting dietary intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Impaired Fasting Glucose Pre Diabetes Liver Fat

Interventions

Dietary interventionDIETARY_SUPPLEMENT

three different diets ( high fat-low carb-low fiber/high carb-low fat - high fiber/high carb-low fat-low fiber)

Eligibility

Sex: ALLMin age: 30 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Impaired fasting glucose(100-125 mg/dl) * HbA1c 5.7-6.4 % * BMI 26-40 kg/sq.m Exclusion Criteria: * MRS contraindication * Pregnant women * Liver disease

Locations (1)

Mayo clinic

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Changes in liver fat content after 12 weeks of intervention

Time frame: 12 weeks

Secondary Outcomes

Change in glucose metabolism after 12 weeks of intervention

Time frame: 12 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.