A Longitudinal Study in Parkinson's Disease (PD) Patients

Tel-Aviv Sourasky Medical Center200 enrolled

Overview

This is a longitudinal study in patients with Parkinson's Disease (PD) carriers of a genetic mutation - substitution of gly with ser in position 2019 (G2019S) in the leucine-rich repeat kinase 2 (LRRK2) gene. The purpose of this study is to explore the association between genetic mutations in the known genes and their influence on disease manifestation over few years of follow up

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Parkinson's Disease

Interventions

neurological examOTHER

motor and cognitive functions

Eligibility

Sex: ALLMin age: 30 Years

Medical Language ↔ Plain English

Inclusion Criteria: * parkinson'd disease patients that already participated in a pasr cross sectional study Exclusion Criteria: * subjects with cognitive decline by the parameters defined in Diagnostic and Statistical Manual of Mental Disorders (DSM)- IV * subjects with psychiatric disorder * subjects unable to sign a consent form

Locations (1)

Tel Aviv Sourasky Medical Center

Tel Aviv, Israel

Outcomes

Primary Outcomes

change from baseline in updrs motor and total scores

Time frame: the participants will be followed for 5 years. the measurements will be taken evry 18 month.

Central Contacts

Anat Mirelman, PhD

CONTACT

972-3-6973014 anatmi@tasmc.health.gov.il

Data from ClinicalTrials.gov

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