Imaging Lung Function Using Oxygen Enhanced MRI

Inclusion Criteria for Lung and/or Airway Disease * Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial: 1. Subjects must be ≥ 18 years of age; 2. Evidence of lung disease or injury by medical history, physical exam, and/or clinical laboratories; * COPD * Asthma * Pre/Post Lung Transplant * Cystic Fibrosis * Emphysema/Other Small Airways Diseases * Lung Transplant 3. Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the trial. 4. Subjects who are willing and able to comply with scheduled visits and other trial procedures. Exclusion Criteria for Subjects with Lung and/or Airway Disease: Subjects presenting with any of the following will not be included in the trial: 1. Unable to undergo a 3.0-Tesla MRI exam of the lungs and chest because of contraindications (e.g. metal in the eye, claustrophobia); 2. Unable to receive 100% oxygen by breathing because of potential hypercapnia ( SpO2 \<90% or FEV1 \< 1 L); 3. Participation in a clinical trial with a study drug that may impact lung function in the past 14 days; or 4. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgment of the investigator, would make the subject inappropriate for entry into this trial. This determination is made by the referring physician based on standard clinical practice. 5. Female; women of childbearing potential must have a confirmed negative urine pregnancy test on the day of the MR scan, prior to the MRI scan. Inclusion Criteria for Normal Subjects Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial: 1. Subjects must be ≥ 18 years of age; 2. Non-smokers, ex-smokers with normal pulmonary function test by spirometry; 3. No Evidence of prior lung disease or lung injury by medical history, physical exam, and/or clinical laboratories; 4. Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the trial. 5. Subjects who are willing and able to comply with scheduled visits and other trial procedures. Exclusion Criteria for Normal Subjects Subjects presenting with any of the following will not be included in the trial: 1. Unable to undergo a 3.0-Tesla MRI exam of the lungs and chest because of contraindications (e.g. metal in the eye, claustrophobia); 2. Unable to receive 100% oxygen by breathing because of potential hypercapnia (SpO2 \<90% or FEV1 \< 1 L) (Note, we consider this highly unlikely in a 'normal' subject); 3. Participation in a clinical trial with a study drug that may impact lung function in the past 14 days; or 4. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgment of the investigator, would make the subject inappropriate for entry into this trial. 5. Female; women of childbearing potential must have a confirmed negative urine pregnancy test on the day of the MR scan, prior to the MRI scan.