Quantification and preferential sites of arterial wall calcification within the coronary and lower legs arteries will be comared between Pseudo-Xanthoma elasticum(PXE) atients and type 2 diabetics and Chronic Kidney disease.
In a previous work we have observed that patients suffering from PXE, a soft-tissue calcifying inherited autosomal disease, exhibited specific structural and functionnal features within the peripheral arteries. We now want to quantify and determine the preferential sites of the arterial wall calcification (Agatston score) between these patients compared to diabetics and patients with chronic renal insufficiency with mediacalcosis. All variables will be collected from a cohort of PXE monitored in our PXE Health and Care centre at the university hospital of Angers. Quantification of the arterial wall calcium load will be performed using helicoidal CT-scan. These variables will be compared to the same measurements performed in type 2 diabetic and chronic kidney disease patients paired by age and gender.
Study Type
OBSERVATIONAL
Enrollment
60
University Hospital
Angers, Pays de la Loire Region, France
RECRUITINGcalcification score
the level of arterial wall calcification determined by a Ct-scan and computed by the Agatston score
Time frame: after inclusion
site of calcification
the anatomical site of arterial wall calcification determined by a Ct-scan and computed by the Agatston score
Time frame: after inclusion
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