Dose and duration of bisphosphonate therapy will increase the likelihood that patients experience delayed healing of non-union fractures.
We intend to review the UWHealth patient database to identify individuals with delayed or nonunion fractures. Subsequently, we will collect associated medical information related to fractures such as age of osteoporosis diagnosis, BMI, previous bisphosphonate treatment, type and location of fracture, time to complete union, other treatment needed for nonunion etc. With this information, we will evaluate the risk of delayed and nonunion fractures in patients previously receiving bisphosphonate treatment compared to a normal population. We also will investigate other potential causes of delayed or nonunion fractures in this population.
Study Type
OBSERVATIONAL
University of Wisconsin
Madison, Wisconsin, United States
The number of patients with delayed healing or non-union fractures with prior bisphosphonate use
This variable will be generated by reviewing diagnosis codes from patients seen at the University of Wisconsin Hospital and Clinics during the time period identified above.
Time frame: 01/01/2000 - 12/31/2011
Evaluation of patient variables (demographic or medical history) related to non-union or delayed healing fractures.
Patients with non-union or delayed healing fractures obtaining care at the University of Wisconsin Hospital or Clinics will have a medical record review conducted.
Time frame: 1/1/2000-12-31-2012
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