A Prospective Randomized Study Comparing the Target Volume for Limited-stage Small Cell Lung Cancer

Inclusion Criteria: * Patients were eligible if they had histologic or cytologic verification of small cell lung cancer (SCLC) and were radiographically confirmed limited-stage * Patients with contralateral mediastinal and ipsilateral supraclavicular lymphadenopathy were also included. * The patients should be between 18 and 75 years old without previous thoracic radiotherapy, chemotherapy or biotherapy. * Karnofsky performance status was ≥ 80. * Forced expiratory volume at 1 second (FEV1) ≥ 1 L. * Had measurable or assessable disease. * Neutrophilic granulocyte ≥ 1.5×109/L, haemoglobin ≥ 100 g/L, platelet count ≥ 100×109/L. * Serum creatine and bilirubin \< 1.5 × the upper normal limit (UNL), aminotransferase \< 2 × UNL. * Weight loss was less than 10% within 6 months before diagnosis. * Written informed consent was required from all patients. Exclusion Criteria: * Patients were ineligible if they had a history of other malignant diseases except for non-melanomatous skin cancer and carcinoma in situ of the cervix, or any contraindications for chemoradiotherapy, malignant pleural and/or pericardial effusion.