The purpose of this research study is to compare the effects on kidney function after performing the removal of a kidney tumor with or without clamping the blood vessels during surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
80
Washington University School of Medicine
St Louis, Missouri, United States
Percent Change From Baseline in eGFR
Renal function following nephrectomy with and without clamping will be assessed using: percent change in eGFR from baseline to 3 months post nephrectomy.
Time frame: baseline and 3 months post nephrectomy
Percent Change From Baseline in Split Renal Function
Renal function following nephrectomy with and without clamping will be assessed using: percent change in split renal function from baseline to 3 months post nephrectomy.
Time frame: baseline to 3 months post nephrectomy
Percent of Observations With Positive Surgical Margins.
Oncologic outcomes will be assessed at the time of nephrectomy based on percent of observations with positive surgical margins.
Time frame: at the time of nephrectomy
Estimated Blood Loss
Perioperative outcomes will be assessed based on estimated blood loss at the time of nephrectomy.
Time frame: At the time of nephrectomy
Percent of Observations With Metastasis
Oncologic outcomes will be assessed based on percent of observations with metastasis on follow-up imaging at 3 years post nephrectomy.
Time frame: 3 years
Operative Time Measured in Minutes.
Perioperative outcomes will be assessed based on operative time measured in minutes at the time of nephrectomy.
Time frame: At the time of nephrectomy
Warm Ischemia Time Measured in Minutes.
Perioperative outcomes will be assessed based on warm ischemia time measured in minutes at the time of nephrectomy.
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Time frame: At the time of nephrectomy.
Percent of Observations With Intra-operative Complications.
Perioperative outcomes will be assessed based on percent of observations with intra-operative complications at the time of nephrectomy.
Time frame: At the time of nephrectomy
Number of Hospital Days Post Nephrectomy.
Perioperative outcomes will be assessed based number of hospital days post nephrectomy.
Time frame: Day of nephrectomy to day of hospital discharge.
Percent of Observations With Postoperative Complications.
Perioperative outcomes will be assessed based on percent of observations with postoperative complications.
Time frame: Within 3 months post nephrectomy.