Effect of Quercetin in Prevention and Treatment of Oral Mucositis

Mashhad University of Medical Sciences20 enrolled

Overview

The study aims to evaluate the effect of Quercetin (a natural flavonoid) on prevention of and treatment of chemotherapy-induced oral mucositis in patients with blood malignancies.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Chemotherapy Induced Oral Mucositis

Interventions

oral quercetin capsulesDRUG

10 cases in case group and 10 cases in control group. Patients in the intervention group were administered two, 250 mg Quercetin capsules daily for 3 weeks. Patients in the placebo group received two placebo capsules containing lactose .Patients were examined every other day for evaluation of initiation and severity of oral mucositis.

PlaceboDRUG

Eligibility

Sex: ALLMin age: 15 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient under chemotherapy * for a hematologic malignancy * the hematologist permits the trial on the patient * agreement of patient for participating in the trial Exclusion Criteria: * presence pf ANY oral lesion at the beginning of the trial * loss of follow up * use of digoxin and cyclosporine * patient death

Locations (1)

Oral Medicine Department of Mashhad dental School

Mashhad, Razavi Khorasan Province, Iran

Outcomes

Primary Outcomes

lower grade of mucositis

grade of mucositis due to WHO criteria

Time frame: 3 weeks

Secondary Outcomes

duration of mucositis

duration of mucositis due to Who criteria

Time frame: 3 weeks of study tiem span and after trial

Data from ClinicalTrials.gov

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