The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.
Reflux esophagitis is thought to be caused by gastric acid that refluxes into the esophagus, causing injury. Newer data suggest that reflux of gastric juice into the esophagus stimulates HIF-2a, which increases production of inflammatory cytokines. These cytokines are thought to lead to reflux esophagitis. The investigators plan to study the relationship of HIF-2a to inflammatory cytokines in patients with known gastroesophageal reflux disease and reflux esophagitis.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
12
Acid-suppressing medications are stopped for all participants the day after baseline assessment. Subsequent evaluations performed while participant is not on acid-suppressing medications.
Dallas VA Medical Center
Dallas, Texas, United States
change in esophageal inflammation from baseline to 14 days
inflammation of the squamous esophageal mucosa will be measured at baseline and at 14 days
Time frame: day 0 and day 14
change in HIF-2a levels from baseline to 14 days
Amount of HIF-2a present will be measured at baseline and at 14 days
Time frame: day 0 and day 14
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