A Safety, Tolerability and Pharmacokinetics Study of R932348 Eye Drops in Patients With Dry Eye Disease

Inclusion Criteria: * Mild to moderate Keratoconjunctivitis Sicca. * A corrected visual acuity in both eyes of 20/40 or better. * An intraocular pressure of \< 21 mm Hg with a difference between eyes of \< 6 mm Hg. Exclusion Criteria: * History or evidence of ocular infection, inflammation, or conjunctivitis within 2 months prior to the first dosing day. * History or evidence of blepharitis requiring the use of antibiotics or eye scrubs within 2 months prior to the first dosing day. * History of herpes simplex keratitis at any time. * Current ocular allergy symptoms. * Recent use of eye medications such as steroids or cyclosporine * Refractive eye surgery within 12 months of the first dosing day. * Other eye surgeries within 4 months of the first dosing day. * Current use of contact lenses or discontinuation of contact lens use within 2 weeks of the first dosing day. * Receipt of any blood or blood products within 90 days prior to the first dosing day. * Participation in any clinical study within 30 days prior to the first dosing day. * History of disease, or currently have a significant illness or abnormal laboratory finding as determined by your study doctor. * Positive for hepatitis B, hepatitis C or HIV. * Smoked regularly within 12 months of first dosing day. * History of substance abuse, drug addiction or alcoholism.